The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could bring about an increase in methadone plasma concentrations, which could trigger potentially lethal respiratory despair. Also, discontinuation of concomitantly applied cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also lead to a rise in meth